On Nov. 29, 1998, when Peyton Manning was a 22-year old rookie, he faced the Baltimore Ravens, led by 35-year-old quarterback Jim Harbaugh.
Final score: Ravens 38, Colts 31.
Harbaugh led a 17-point fourth-quarter rally.
On Sept. 26, 1999, Manning, 23, and Harbaugh, 36, were once again opposing starting quarterbacks, as the Colts visited the San Diego Chargers.
Final score: Colts 27, Chargers 19.
Manning led a 14-point fourth-quarter rally.